![]() ![]() Extracorporeal Photopheresis for Bronchiolitis Obliterans Syndrome Following Lung Transplant.Allogeneic Hematopoietic Stem Cell Transplant for Sickle Cell Disease.Allogeneic Hematopoietic Stem Cell Transplant for Myelofibrosis.Allogeneic Hematopoietic Stem Cell Transplant for Multiple Myeloma.Allogeneic Hematopoietic Stem Cell Transplant for MDS.The ASBMT will periodically review these guidelines and will update them as new evidence becomes available.Īllogeneic transplantation Autologous transplantation Clinical trials Hematopoietic cell transplantation Indications Routine care Standard of care.Ĭopyright © 2015 American Society for Blood and Marrow Transplantation. Indications for HCT were categorized as follows: (1) Standard of care, where indication for HCT is well defined and supported by evidence (2) Standard of care, clinical evidence available, where large clinical trials and observational studies are not available but HCT has been shown to be effective therapy (3) Standard of care, rare indication, for rare diseases where HCT has demonstrated effectiveness but large clinical trials and observational studies are not feasible (4) Developmental, for diseases where preclinical and/or early phase clinical studies show HCT to be a promising treatment option and (5) Not generally recommended, where available evidence does not support the routine use of HCT. This white paper presents the recommendations from the task force. The American Society for Blood and Marrow Transplantation (ASBMT) established a multiple-stakeholder task force consisting of transplant experts, payer representatives, and a patient advocate to provide guidance on "routine" indications for HCT. Indications for HCT continue to evolve as research refines the role for HCT in established indications and identifies emerging indications where HCT may be beneficial. With advances in transplantation technology and supportive care practices, HCT has become safer, and patient survival continues to improve over time. 15 Adult Bone Marrow Transplant Service, Memorial Sloan Kettering Cancer Center, New York, NY.Īpproximately 20,000 hematopoietic cell transplantation (HCT) procedures are performed in the United States annually.14 Malignant Hematology & Stem Cell Transplantation, The Ottawa Hospital, Ottawa, ON.13 Bone Marrow Transplantation Unit, Great Ormond Street Hospital for Children, London, UK.12 Division of Hematology/Oncology, Vanderbilt University Medical Center, Nashville, TN.11 Center for International Blood and Marrow Transplant Research, Milwaukee, WI.10 Division of Hematology and Oncology, Medical College of Wisconsin, Milwaukee, WI.9 Division of Hematology/Oncology, Mayo Clinic, Phoenix, AZ.8 Department of Pediatrics, University of Minnesota, Minneapolis, MN. ![]() 6 Adult BMT Unit, University Hospitals Bristol NHS Foundation Trust, Bristol, UK.5 Cigna LifeSource Transplant Network, Pittsburgh, PA.4 Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX.3 Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA.2 Payer Policy, National Marrow Donor Program, Minneapolis, MN.1 Blood & Marrow Transplant Program, Cleveland Clinic, Cleveland, OH.
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